The Mother Centriole Plays an Instructive
\nRole in Defining Cell Geometry<\/B><\/p>\n
ABSTRACT:<\/U><\/p>\n
Centriole positioning is a key step in establishment and propagation of cell geometry, but the mechanism of this
\npositioning is unknown. The ability of pre-existing centrioles to induce formation of new centrioles at a defined angle
\nrelative to themselves suggests they may have the capacity to transmit spatial information to their daughters. Using
\nthree-dimensional computer-aided analysis of cell morphology in Chlamydomonas, we identify six genes required for
\ncentriole positioning relative to overall cell polarity, four of which have known sequences. We show that the distal
\nportion of the centriole is critical for positioning, and that the centriole positions the nucleus rather than vice versa. We
\nobtain evidence that the daughter centriole is unable to respond to normal positioning cues and relies on the mother
\nfor positional information. Our results represent a clear example of \u2018\u2018cytotaxis\u2019\u2019 as defined by Sonneborn, and suggest
\nthat centrioles can play a key function in propagation of cellular geometry from one generation to the next. The genes
\ndocumented here that are required for proper centriole positioning may represent a new class of ciliary disease genes,
\ndefects in which would be expected to cause disorganized ciliary position and impaired function.<\/p>\n","protected":false},"excerpt":{"rendered":"
The Mother Centriole Plays an Instructive Role in Defining Cell Geometry ABSTRACT: Centriole positioning is a key step in establishment and propagation of cell geometry, but the mechanism of this positioning is unknown. The ability of pre-existing centrioles to induce …<\/p>\n