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β-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters
β-Alanine supplementation aug-
ments muscle carnosine content and attenuates fatigue during
repeated isokinetic contraction bouts in trained sprinters. J Appl
Physiol 103: 1736–1743, 2007. First published August 9, 2007;
doi:10.1152/japplphysiol.00397.2007.—Carnosine (-alanyl- L –
histidine) is present in high concentrations in human skeletal muscle.
The ingestion of -alanine, the rate-limiting precursor of carnosine,
has been shown to elevate the muscle carnosine content. We aimed to
investigate, using proton magnetic resonance spectroscopy (proton
MRS), whether oral supplementation with -alanine during 4 wk
would elevate the calf muscle carnosine content and affect exercise
performance in 400-m sprint-trained competitive athletes.
J Appl Physiol 103: 1736-1743, 2007.
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