The Other Kind of Seven-Year Itch

THE ITCH by Atul Gawande from the New Yorker

Fascinating article, albeit with occasionally disturbing imagery, on itching and phantom pain.

Now various phenomena became clear. Itch, it turns out, is indeed inseparable from the desire to scratch. It can be triggered chemically (by the saliva injected when a mosquito bites, say) or mechanically (from the mosquito’s legs, even before it bites). The itch-scratch reflex activates higher levels of your brain than the spinal-cord-level reflex that makes you pull your hand away from a flame. Brain scans also show that scratching diminishes activity in brain areas associated with unpleasant sensations.
But some basic features of itch remained unexplained—features that make itch a uniquely revealing case study. On the one hand, our bodies are studded with receptors for itch, as they are with receptors for touch, pain, and other sensations; this provides an alarm system for harm and allows us to safely navigate the world. But why does a feather brushed across the skin sometimes itch and at other times tickle? (Tickling has a social component: you can make yourself itch, but only another person can tickle you.) And, even more puzzling, how is it that you can make yourself itchy just by thinking about it?

Photochrome


Photochrome
You give us those nice bright colors
You give us the greens of chemistry
Makes you think all the world’s a funky lab, oh yeah!

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Zap the molecule with UV and it turns green. This is due (as I understand it) to the molecule changing to another state (isomer) — and not simply fluorescence — where it then has a different absorption spectrum, so in this example it looks green. When you remove the UV, it reverts to the original state and becomes clear again, and it’s doing this quite rapidly.